Diabetes Care
“The use of Medical Hyperspectral Technology to evaluate microcirculatory changes in Diabetic Foot Ulcers and to predict clinical outcomes.”
Dr. Lalita Khaodhiar, MD, et al.
Microvascular Complications
“MHSI May Predict Clinical Outcomes in Diabetic Foot Ulcers”
The Lancet
“Early changes in the skin microcirculation and muscle metabolism of the diabetic foot.”
Robert L. Greenman, PhD
Additional References
Medical Applications of Hyperspectral Technology
Freeman J, Panasyuk S, Pease, E, Schomacker, K. Medical hyperspectral imaging (MHSI) for the assessment of systemic physiology, Oral Presentation, 16th World Congress of the World Society of Cardio-Thoracic Surgeons, Ottawa, Canada, August 18, 2006.
Freeman J, Panasyuk S. Hyperspectral imaging in medicine. Chance Laboratory Seminar, University of Pennsylvania, Philadelphia, June 2005.
Afromowitz MA, Callis JB, Heimbach DM, DeSoto LA, Norton MK. Multispectral imaging of burn wounds: a new clinical instrument for evaluating burns. IEEE Trans Biomed Eng 1998; 35 (10): 842-50.
Downs F, Rish J, Freeman J. Multispectral imagery applications for medical diagnostics. Advanced Technology Applications to Combat Casualty Care (ATACCC), St. Petersburg, FL, May, 1997.
Freeman JE, Downs F, Marcucci L, Lewis EN, Blume B, Rish J., Multispectral and hyperspectral imaging: applications for medical and surgical diagnostics. Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, 1997; 701-702.
Diabetes and Peripheral Vascular Disease
Dinh T, Panasyuk S, Freeman J, Panasyuk AA, Lew R, Brand D, Lima C, Giurini JM, Lyons TE, Khaodhiar L, Veves A. Medical hyperspectral imaging (MHSI) evaluation of microcirculatory changes to predict clinical outcomes: application to diabetic foot ulcers. Poster #P-16, Society of Vascular Medicine and Biology 17th Annual Scientific Session, June 2006 and Vascular Medicine; Vol 11, Supp 1, S7, June 2006.
Dinh T, Panasyuk S, Jiang C, Freeman J, Panasyuk AA, Nerney M, Lew R, Brand D, Lima C, Giurini JM, Lyons TE, Khaodhiar L, Veves A. The use of medical hyperspectral imaging (MHSI) to evaluate microcirculatory changes in diabetic foot ulcers and predict clinical outcomes. Abstract presentation and publication number: 106-OR, Oral session: Diabetic Foot – More than the Clinical Basics, American Diabetes Association 66th Scientific Sessions, June 10, 2006 and Diabetes; Vol 55, Supp.1, A106, June, 2006.
Freeman J, Panasyuk S, Schomacker K. Medical hyperspectral imaging: (MHSI) – wound healing, diabetic foot ulcers and progression of systemic disease. Grand Rounds, Endocrinology, Cleveland Clinic Foundation, February 2006
Dinh T, Panasyuk SV, Tracey BH, Khaodhiar L, Lyons TE, Rosenblum BI, Giurini JM, Freeman JE, Veves A. The use of medical hyperspectral imaging (MHSI) to identify patients at risk for developing diabetic foot ulcers. Poster #1106-P, American Diabetes Association 65th Annual Sessions, June, 2005 and Diabetes, Vol 54, Supp. 1, A270, June 2005.
Greenman RI, Panasyuk S, Wang X, Lyons TE, Dinh T, Longorio L, Giurini JM, Freeman J, Khaodhiar L, Veves A. Early changes in the skin microcirculation and muscle metabolism of the diabetic foot. Lancet 2005; 366(12): 1711-1718.
Kellicut D, Mansfield JR, Lew RA, Lewis EN, Freeman JE, Sidawy A. Hyperspectral imaging of diabetic foot conditions and peripheral arterial disease, Oral presentation, 18th Annual Meeting of the Eastern Vascular Society, May 2004.
Zuzak K, Schaberle MD, Levin IW, Lewis EN, Freeman JE, McNeil JD, Cancio LC. Visible and infrared hyperspectral visualization in normal and ischemic tissue. Proceedings 21st Annual International Conference of the IEEE and Engineering in Medicine and Biology Society, 1999; 181.
Khaodiar, L, Dinh T, Panasyuk S, Schomacker K, Freeman J, Panasyuk AA, Lew R, Lima C, Giurini JM, Lyons TE, Veves A. The use of medical hyperspectral technology (MHT) to evaluate microcirculatory changes in diabetic foot ulcers and predict clinical outcomes. Submitted to Diabetes Care.
Macsata R, Freeman J, Panasyuk SV, Schomacker KT, Lew RA, Sidawy A. The use of hyperspectral technology in acute limb ischemia. In preparation for submission to The Journal of Vascular Surgery.
Shock and Biodefense
Cancio LC, Batchinski AI, Mansfield JR, Panasyuk S, Hetz K, Martini DK, Jordan BS, Lew RA, Tracey B, Freeman JE. Hyperspectral imaging: a new approach to the diagnosis of hemorrhagic shock. Journal of Trauma, Vol 60, Supp. 5, May, 2006, 1087-1095.
Freeman JE, Panasyuk SV, Holcomb JB, Cancio LC, Hopmeier MJ, Cooke WI, Convertino VA. Use of near-infrared medical hyperspectral imaging (MHSI) in the evaluation of hemodynamic compromise in human subjects. Poster # 30, Eastern Association for the Surgery of Trauma, Jan, 2006.
Freeman JE, Panasyuk SV, Lew RA, Holcomb JB, Hopmeier MJ, Cooke WI, Convertino VA. Diagnosis and evaluation of human hemodynamic compromise using medical hyperspectral imaging (MHSI) as a stand-off non-invasive method. Poster # 9411, American Heart Association, Dallas, Nov 2005.
Panasyuk SV, Freeman JE, Lew RA, Tracey B, Jordon B, Batchinsky AI, Hopmeier MJ, Cancio LC. Use of a hyperspectral shock index for the early diagnosis of hemorrhagic shock. Poster # 11090, American Heart Association, Dallas, Nov 2005.
Freeman, JE, Panasyuk SV, Hopmeier MJ, Lew RA, Batchinski AI, Cancio LC. The evaluation of new methods of hyperspectral image analysis for the diagnosis of hemorrhagic shock. Poster #18, American Association for the Surgery of Trauma, Atlanta, Sept 2005.
Panasyuk SV, Freeman JE, Cooke WI, Hopmeier MJ, Convertino VA. Initial demonstration in human subjects of medical hyperspectral imaging (MHSI) as a novel standoff non-invasive method for diagnosing and measuring hemodynamic compromise. Poster #17, American Association for the Surgery of Trauma, Atlanta, Sept 2005.
Freeman JE, Panasyuk SV, Lew RA, Hopmeier MJ, Holcomb J, Cooke W, Convertino V. The development of hyperspectral imaging as a stand-off tool for the evaluation of shock: human studies of lower body negative pressure induced hemodynamic compromise. Advanced Technology Applications to Combat Casualty Care (ATACCC), St. Petersburg, FL, Aug 2005.
Cancio LC, Mansfield JR, Batchinski AI, Jordan BS, Martini DK, Panasyuk SV, Lew RA, Freeman JE. Hyperspectral imaging: a non-invasive, non-contact approach to the diagnosis of hemorrhagic shock. Poster #P2, Eastern Association for the Surgery of Trauma, Dec, 2004 and Journal of Trauma, Vol 57, Issue 6, p.1383, Dec 2004.
Freeman J, Levin R. Commercial prospects for medical surveillance technology. American Med Informatics Association Annual Symposium, Washington DC, Nov 2003.
Gillies RJ, Levin RK, Mansfield JR, Hopmeier MJ, Freeman JE. Use of hyperspectral imaging to profile cutaneous responses to bioweapons: a concept paper. Proc. SPIE: Technologies, Systems, and Architectures for Transnational Defense II; Vol. 5072, p. 32-44, Aug 2003, Mark K. Hamilton, Vince C. Boles; Eds.
Gillies R, Freeman JE, Cancio LC, Brand D, Hopmeier MJ, Mansfield JR. Systemic effects of shock & resuscitation monitored by visible hyperspectral imaging. Diabetes Technology. & Therapeutics, Volume 5, Number 5, 2003, 847-855.
Cancio LC, Batchinsky A, Lewis EN, Freeman JE, Lew RA, Mansfield JR. Non-invasive determination of hypovolemic shock using hyperspectral imaging; Federation of Applied Chemistry & Spectroscopy Societies (FACSS) Annual Meeting, Ft. Lauderdale, FL, 2003.
Cancio LC, Mansfield JR, Brand D, Kerby J, Freeman J, Hopmeier M. Visible hyperspectral imaging: monitoring the systemic effects of shock and resuscitation. Proc SPIE Int Soc Opt Eng, 2002; 4614-27.
Breast Cancer
Freeman JE, Yang S, Panasyuk SV, Lew RA, Ngo D, Faller DV, Rogers AE. In situ evaluation of residual breast tumor and tumor grade using medical hyperspectral imaging (MHSI). Journal of Clinical Oncology, Vol 24, No. 18S, Part 1; 582s; June, 2006.
Freeman JE, Panasyuk SV, Shi Y, Rogers AE. The use of medical hyperspectral imaging (MHSI) to identify residual breast tumor in the surgical resection bed. Poster #P64-24, Fourth Annual Era of Hope Meeting, Philadelphia, June 2005 and Era of Hope: Department of Defense Breast Cancer Research Program Meeting Proceedings; 453, June 2005.
Panasyuk SV, Freeman JE, Shi Y, Rogers AE. Advantages of intraoperative medical hyperspectral imaging (MHSI) for the evaluation of the breast cancer resection bed for residual tumor. Journal of Clinical Oncology, Vol 23, No. 16S, Part 1; 55s; June 2005.
Freeman JE, Panasyuk SV, Shi Y, Rogers AE. The use of medical hyperspectral imaging (MHSI) to identify residual breast tumor in the surgical resection bed. Era of Hope: Department of Defense Breast Cancer Research Program Meeting Proceedings, 2005, 453.
Freeman JE, Panasyuk SV, Shi Y, Rogers AE. The use of medical hyperspectral imaging (MHSI) to identify residual breast tumor in the surgical resection bed. Poster #P64-24, Fourth Annual Era of Hope Meeting, Philadelphia, 2005.
Freeman JE, Shi Y, Panasyuk SV, Rogers AE. Medical hyperspectral imaging (MHSI) of 1, 2-dimethylbenz(a)anthracene (DMBA)-Induced Breast Tumors in Rats. Poster #1001, 27th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, Dec, 2004 and Breast Cancer Research and Treatment, Vol 88, Supp 1, S51, Dec 2004.
Freeman JE, Yang S, Panasyuk SV, Faller, DV, Ngo D, Rogers AE. Medical hyperspectral imaging to facilitate residual tumor identification during resective surgery. Submitted for publication.